MOSI is a not-for-profit, community-based institution and educational resource that is dedicated to advancing public interest, knowledge, and understanding of science, industry, and technology. MOSI's core ideology is to make a difference in people's lives by making science real for people of all ages and backgrounds.

MOSI today is the result of 52 years of growth and maturity reflecting both the institution and the surrounding community. The passage of time has seen MOSI change in name, location, and size. However, its general purpose, that of providing informal science education, has remained essentially unchanged. In 1962, Hillsborough County first approved funding for a youth museum in Sulphur Springs on the banks of the Hillsborough River. Later renamed the Museum of Science and Natural History, this small museum provided natural science exhibits and education programs to children and adults. MOSI is accredited by the American Association of Museums and by the Association of Science-Technology Centers.

Exhibits
IMAX Dome Theatre
Planetarium
Science Works Theater
Children's Science Center